PROTOCOLS

PROTOCOLS & SELF-GUIDED WORK


After much demand… it’s finally here…..

Over the past decade, I’ve been asked countless times how I approach microdosing…
how to begin, how to work with the medicine intentionally, and how to create lasting change rather than simply chase an experience.

This protocol is the culmination of years of personal practice, ongoing research, ceremony facilitation, and supporting hundreds of people on their own healing journeys.

It is not simply a dosing guide.
It is a framework for working with the medicine consciously, respectfully, and with intention.

This is not about escape.
It is about learning to see more clearly.

Here you will find a curated collection of self-guided protocols designed to support awareness, nervous system regulation, and deeper connection to self.

These are not quick fixes.
They are structured pathways to help you slow down, observe, and work with your patterns in a more intentional way.

Each protocol combines:

  • clear structure
  • guided reflection
  • integration practices
  • nervous system support

Move at your own pace.
Return to yourself, one step at a time.


 AVAILABLE PROTOCOLS

AMANITA MUSCARIA PROTOCOL

A grounded, nervous-system-based approach to working with Amanita.

Traditionally associated with calming and regulating the system, this protocol is designed to support:

  • reduced internal noise
  • improved sleep and recovery
  • emotional stability
  • deeper connection to the body

This is not a stimulating experience.
It is a return to stillness.

WHAT YOU RECEIVE :  AMANITA PROTOCOL

  • Structured dosing rhythm (3 days on / 4 days integration + monthly reset)
  • Clear dosage guidance for gradual and safe entry
  • Morning and evening dosing options (including sleep support)
  • Step-by-step usage guidance
  • Nervous system regulation practices
  • Guided journaling prompts
  • Somatic and lifestyle support practices
  • Energetic framework for grounding and integration

Designed to support calm, clarity, and balance.

MELMAC MICRODOSING PROTOCOL

A structured framework for self-awareness, clarity, and inner recalibration. Melmac is a variety of Psilocybe cubensis, known for its potency and commonly used in microdosing practices.

 

Designed to support:

  • pattern recognition
  • emotional awareness
  • increased presence
  • gentle cognitive clarity

This is not about escape.
It is about learning to see more clearly.

WHAT YOU RECEIVE : MELMAC PROTOCOL

  • Structured microdosing framework (3 days on / 4 days integration + monthly cycle)
  • Clear dosage guidance (beginner to advanced)
  • Step-by-step instructions for safe use
  • Daily journaling prompts for insight and reflection
  • Integration practices to support real change
  • Nervous system support tools
  • Complementary modalities (breathwork, movement, stillness)
  • Daily tracking framework to monitor progress

A framework to help you understand yourself more clearly.


Psilocybin (Melmac)

Works primarily through the serotonin system.

Often associated with:

  • Increased neuroplasticity
  • Emotional processing
  • Expanded awareness
  • New perspectives
  • Cognitive flexibility

Amanita muscaria

Works primarily through the GABA system.

Often associated with:

  • Deep relaxation
  • Nervous system regulation
  • Reduced mental overactivity
  • Dream-like states
  • Rest and restoration

A Beautiful Comparison for Your Booklets

MELMAC (Psilocybin)

Primary Compound: Psilocybin
Converted To: Psilocin
Pathway: Serotonin (5-HT2A) System
Often Associated With: Awareness • Insight • Neuroplasticity • Emotional Processing • Expanded Perspective

AMANITA MUSCARIA

Primary Compound: Muscimol
Precursor: Ibotenic Acid
Pathway: GABA-A System
Often Associated With: Stillness • Rest • Nervous System Regulation • Dream States • Inner Stability

 

 

NOTES OF CAUTION :

Clients taking antidepressants or other psychiatric medications require an individual screening assessment. Microdosing recommendations are not provided solely on the basis of medication lists, and clients should not reduce or discontinue prescribed medication without the guidance of their treating clinician.

Combining Microdosing (LSD, Psilocybin) With Medication Or

Supplements

Below is a compiled list of medications, supplements, and drugs that have been found NOT to cause any adverse side effects when combined with microdosing.

This list does not guarantee that microdosing is safe and/or effective in combination with the listed medications.

• This list applies to microdosing with LSD and psilocybin only. Other microdosing substances may or may not combine well with your medication or supplements.

• If you take two or more medications, or have a somatic illness or a mental

health condition, it is advised to consult a medical doctor or psychiatrist who’s

well versed in psychedelics and medication interactions prior to microdosing.

• Always consult your MD or psychiatrist if you want to combine, taper or

discontinue any of your medications.

 

What if my medication is not on the list?

If your medication is not on this list, this means there is insufficient data to support

that microdosing is safe and/or effective. It is advised to consult a medical doctor or psychiatrist who’s well versed in psychedelics and medication interactions prior to microdosing.

 

Common Medications & Substances

Reported as Compatible with Microdosing

(Unless otherwise advised by your physician)

Important Exceptions / Use Caution

Do not microdose while taking:

• Tramadol (Ultram)

• Lithium

Consult a healthcare professional before microdosing if taking prescription

medications, especially psychiatric, cardiovascular, or neurological medications.

Pain Relief

• Acetaminophen / Paracetamol (Tylenol)

• Aspirin

• Codeine

• Dihydrocodeine (Co-dydramol)

• Hydrocodone (Vicodin, Norco)

• Ibuprofen (Advil, Motrin)

• Naproxen (Aleve)

• Tramadol (Ultram) ⚠ Do not microdose while taking Tramadol

Heart / Blood Pressure

• Amiodarone (Cordarone, Nexterone)

• Hydrochlorothiazide (HCTZ)

• Lisinopril (Prinivil, Zestril)

• Losartan (Cozaar)

• Ramipril

• Spironolactone (Aldactone)

• Telmisartan (Micardis)• Valsartan (Diovan)

Birth Control / Hormonal Contraception

• Aubra

• Hormonal contraceptive pills

• Marvelon

• Mirena

• NuvaRing

• Tri-Cyclen

Antacids / GERD

• Esomeprazole (Nexium)

• Pantoprazole (Protonix)

• Ranitidine (Zantac)

Antibiotics

• Clindamycin (Cleocin, Dalacin)

• Doxycycline

• Minocycline (Minocin)

• Penicillin (Bicillin)

Antifungals

• Fluconazole (Diflucan)

Focus / ADHD Medications

• Amphetamine (Adderall)

• Bupropion (Wellbutrin)

• Dextroamphetamine (Dexedrine)

• Lisdexamfetamine (Vyvanse)

• Methylphenidate (Ritalin, Biphentin)

• Modafinil (Provigil)Sleep Support

• Melatonin

• Zopiclone (Imovane, Zimovane)

• Zolpidem (Ambien, Stilnox)

Antihistamines / Allergy

• Cetirizine (Zyrtec)

• Diphenhydramine (Benadryl)

• Loratadine (Claritin)

Benzodiazepines (Anxiety / Sleep / Seizure)

• Alprazolam (Xanax)

• Clonazepam (Klonopin)

• Diazepam (Valium)

• Flurazepam

• Lorazepam (Ativan)

Other Anxiolytics

• Etizolam

• Propranolol

Parkinson’s Medications

• Levodopa

• Pramipexole

Cholesterol Medications

• Atorvastatin (Lipitor)

• Rosuvastatin (Crestor)

• Simvastatin (Zocor)

• Statins

Racetams / Nootropics• Aniracetam

• Phenylpiracetam

• Piracetam

Mood Stabilizers / Antipsychotics

• Aripiprazole (Abilify)

• Buspirone (Buspar)

• Lamotrigine (Lamictal)

• Lithium ⚠ Do not microdose while taking Lithium

• Quetiapine (Seroquel)

Diabetes

• Metformin (Glucophage)

Anticonvulsants / Neurological

• Baclofen

• Carbamazepine (Tegretol)

• Cyclobenzaprine (Flexeril)

• Gabapentin

• Mirtazapine

• Primidone

• Sodium Valproate

• Topiramate

• Tizanidine (Zanaflex)

Thyroid / Hormonal Support

• Levothyroxine (Synthroid)

• Methimazole / Thiamazole

• Nature-Throid

Antidepressants

• Bupropion (Wellbutrin)• Citalopram (Celexa)

• Desvenlafaxine (Pristiq)

• Doxepin

• Duloxetine (Cymbalta)

• Escitalopram (Lexapro)

• Fluoxetine (Prozac)

• Paroxetine (Paxil)

• Sertraline (Zoloft)

• Venlafaxine (Effexor)

Breathing / Asthma / COPD

• Salbutamol (Albuterol)

• Beclometasone

• Montelukast (Singulair)

• Cetirizine (Zyrtec)

Antivirals

• Nitazoxanide

Recreational Substances

• Alcohol

• Amphetamine (Speed)

• Cannabis

• Heroin

• Kratom

• Nicotine

Anti-inflammatory / Immune

• Mesalazine (Octasa)

• Hydroxychloroquine (Quensyl)

Erectile Dysfunction

• Tadalafil (Cialis)Alcohol Dependence Treatments

• Acamprosate (Campral)

• Disulfiram (Antabuse)

• Naltrexone

Hormones & Steroids

• Dexamethasone

• DHEA

• Estradiol

• Estrogen (Premarin)

• Norethindrone / Ethinyl Estradiol

• Prednisone

• Progesterone (Prometrium)

• Spironolactone

• Testosterone

Supplements Commonly Used

Alongside Microdosing

• 5-HTP

• Albizia

• Ashwagandha

• B Vitamins (B6, B12, B100)

• Biotin

• Brahmi

• Bromelain

• Caffeine

• Calcium

• Chaga

• Chlorophyll

• Choline

• CoQ10

• Cordyceps

• Creatine• Curcumin (Turmeric)

• Eleuthero

• EPA/DHA

• Fish Oil

• Ginseng

• Glucosamine

• Iodine / Kelp

• Iron

• L-Theanine

• Lemon Balm

• Lion’s Mane

• Maca

• Magnesium

• MCT Oil

• MSM

• Milk Thistle

• Multivitamins

• Omega 3/6/9

• Passionflower

• Phosphatidylserine

• Probiotics

• Pycnogenol

• Reishi

• Rhodiola

• Selenium

• Shatavari

• Skullcap

• St. John’s Wort

• Taurine

• Tulsi

• Turkey Tail

• Vitamins C, D, D3, K, K2

• Zinc

Disclaimer

The content on this website and the other Microdosing Institute channels is for informational and educational purposes only, and does not substitute professional medical advice or consultation with healthcare professionals.

If you are seeking medical advice, diagnose, or treatment, we advise you to consult a medical professional or healthcare provider. Equally, we cannot help with the sourcing of illegal substances.